Tuesday, April 15, 2008
Congee
Saturday, March 22, 2008
Creativity
Saturday, January 12, 2008
Philadelphia
When I woke up, she was reading. I knew then that she, like me, was a scientist, for she was reading the latest issue of Nature, the preeminent science weekly. I just read the same issue. I said to her that there was an amazing report in that issue that some people had managed to turn adult human cells into pluripotent stem cells. She paused her reading and looked at me for a second, without saying anything. Then she said yes, it was a real breakthrough. The ice was broken.
She was a Ph.D. student in the University of Pennsylvania, in the department of chemical engineering. She was writing her thesis on computer simulation of amyloid formation, and was visiting her collaborator in Princeton. She said it was quite boring. She felt that she was wasting her life doing things that she didn't believe in, while other people were doing great things like making stem cells out of human skin. She said that she went into science with illusions of grandeur, but all there seemed to be for her was mediocrity.
I assured her that it was fine. I told her that it could be mathematically proven that at least 90% of people wouldn't make it into the top 10%. I told her that research was just another profession, above all one should find a high-paying employer.
The train stopped, a few people at the far end of the car got off. But no one stirred near us.
She said that she had dreams of doing great science. She had ideas of unifying biology into a theoretical framework like physics. She had hoped to invent cure for a disease. But that was before graduate school. Now she only wanted to publish as many papers as she could, so that she could eventually find a faculty position in a decent school.
She said that these days the number of publications alone does not count. Nor does the quality of the science. What matters is where one publishes. You are nobody if you haven't published in Science or Nature. She had just submitted a paper to Science, after it was first rejected by Nature. If Science would reject it, she was going to try Cell, Proceedings of the National Academy of Sciences, Plos Biology, Physical Review Letters, Biophysical Journal, in that order.
"Last time my paper ended up in PRL. It is like a dumpster and pretty much publishes any biological paper written by physicists." She said. "This time I hope I can at least get into Plos Biology."
I told her that I had a paper initially submitted to Science but it ended up in American Journal of Physics. She laughed. She thought that I made up the name of the journal. I didn't.
We both felt that bitter irony. We doubt the scientific merit of our own work, therefore we seek vindication by trying to publish it in high-profile journals. We are content with the illusion of doing great science as long as others get the same illusion about us. We are happy fooling ourselves as long as we can fool others. There is no need for true greatness as long as we put up a great front.
We griped more about the status quo of science. We felt trapped.
Then for a minute we were both silent. We looked into each other's eyes and knew that we shared the same sadness, that we were tormented by the same self-pity of unfulfilled lives. Suddenly it was unbearable. Our sadness reflected in each other's eyes began to multiply, like a tortured soul standing between two mirrors. We both looked away. Then she turned to me and took my hand into hers. It should have surprised me but it didn't. It was company in shared misery. Our eyes met again, but in them lust had taken place of sadness. She kept her eyes open until our lips touched. She lead my hand onto her breasts and then let it go. I slided my hand underneath the bra and felt her flesh, pulsating with the movement of the train. Then her hand sought me. When she touched it, it answered. She leaned against me so that her body covered both our hands. My hand glided down her body and found her wetness. A moan. We breathed heavily. Crushing every sound of ours was the noise of the train. All around the train was emptiness. Except for the lamp posts that threw fleeting patches of light over us. Sometimes her hand halted, withdrew, hesitated, afraid, expectant. Then it came back. Her grip tightened as I tapped her intensifying wetness. Then the train stopped. More people got off the train. The conductor walked through the aisle. Her body left mine. We knew it was over. The sorrow had returned to us, the sorrow of feeling cheated by our circumstances, the sorrow of missed lives that could have been. More stops in endless emptiness. We pretended to sleep. When the train arrived in Philadelphia we parted like strangers.
Saturday, August 25, 2007
The Last Ottoman
Every Tuesday afternoon, when I take my bath in Cağaloğlu Hamami, Mustafa Ozkan appears fatter than I remember him from the week before. How my masseur manages to develop that corpulence despite his strenuous profession – all day long he pummels and presses and twists and kneels and steps up and down on his customers, in all that heat in the sauna room – puzzles many bathers. “It’s the baklavas.” Mustafa will say, with a carefree smile. Yet fattening Mustafa more than the sweet pastry is the melancholic abandon that has bound him since the day Seifka Pamuk left
I lie face down, my chest on the marble slate heated by the steam circulating in the octagonal room. Mustafa takes off his T-shirt, revealing his hairy chest and pear-shaped belly. He puts his hands on my back. “It’s tense here.” he says, as always, and starts to rub along my spine. Mustafa has very strong hands, which is why I choose him for my massages. He presses his fingers deep into my flesh, and I can sense his almost sadistic pleasure of inflicting the transient pain on another man. After the pressing comes the pummeling, and then the twisting backward of my arms as far as they will go without dislocation. In the culminating act, Mustafa steps onto my back with both his feet and walks from my waist to just below my neck and then down again. Soon we are both covered in sweat, Mustafa’s sweat. I feel a little disgust, but soon enough soap comes in and dissolves it.
Mustafa steps out of the room – it’s tea time – leaving me wash off the soap myself. The afternoon sun pours in through the star-shaped windows in the domed ceiling, and, when shining on my skin, it elicits a different sensation of warmth than the moist steam. I turn the faucets fully open, and wait until water has filled the marble basin. I reach in and touch the bottom, just as I touched it when the bath first opened its doors in 1741. I let my fingers register how the stone has become polished by two hundred and sixty six years of running water. Sultan’s subjects, rich and poor, have cleansed themselves under this same roof. Now it caters to the city’s well-heeled residents and Western tourists. The place has otherwise changed little, like me.
The place where a man truly belongs is where he wishes to die. My city is Istanbul – I have peregrinated the world but have always come back to the banks of Marmara – yet I cannot die, not since my fateful encounter with Shabalba when the crushing snow cut off the pursuing Russian cavalry but also stranded me for a week in the high Urals. I will live my endless days of ennui, in this city of solitude and melancholy.
I walk by cafés where people are smoking hookah and playing backgammon. I walk by restaurants where American tourists applaud Dervish dancers. I don’t stop. I pass by a small mosque in disrepair adjoined by a dilapidated wooden house, in front of which a wrinkle-faced woman is hanging her washed clothes. In an ice cream stand, a man in white robe is performing the traditional trick of serving Turkish ice cream: his swift wrist keeps the ice cream at the tip of a long rod tantalizingly close to yet always out of reach of his customer's grasp. The onlooking Chinese backpackers laugh in amusement, but I walk on. Oh, the simple delight of seeing something for the first time! Now, I am cursed with a jaded memory, like a film that has been exposed so many times that on it only blank remains.
Friday, August 17, 2007
Mechanism of Na+/H+ antiporting
Secret ways of the antiporter.
This family of membrane proteins,
Trading one sodium inside cell, with
Two protons outside,
So all life is alive, in acid and brine.
Its structure recently unveiled,
Using extraction from E. Coli.;
Yet its method of act,
Hitherto uncomprehended.
This method we tell, by a host of
Molecular simulations;
By thinking and rethinking of
Clues already seen in labs:
Three membranous aspartates,
Protonating and deprotonating,
Move the protein in action.
Asp a hundred sixty four,
Deprotonating and protonating,
Binds and releases sodium ions;
Asp a hundred sixty three,
Protonating and deprotonating,
Opens the gate to peri- and cyto- plasm.
Asp a hundred and thirty three,
Be the pKa high, be its charge negative,
Keeps the antiporting in flux.
To ascertain our theory,
We return to the bench,
Modifying the protein by
Mutagenesis.
Happily the outcome,
With our predictions agreed.
Thursday, August 02, 2007
Sunday, April 29, 2007
Keep the Change, Stupid!
Keep the Change, this concept of aided saving, is laughable at best, if not entirely senseless. Having outgrown my piggy bank in teens, I only saved quarters for parking meters and washing machines, and I had barely saved enough quarters before the smart cards caught on in the laundry rooms. If you count on loose changes for your savings, you'd better vote for a financially responsible president so that social security will always be there for you. With two purchases a day, 50 cents of change per purchase, you will save $30 a month, $360 a year. Not exactly helpful for your retirement, or your children's college tuition.
That's why BOA disguised this laughable concept in their advertisements: it's not just about helping you save your money; it's about putting those otherwise lost coins into real use. A misdirection, but a clumsy one. If you are using a debit card, there will be no loose change to begin with. So why round up the price and put the difference into the savings account? Why not just keep the change in the checking account for your next purchase, and put aside larger sums regularly into savings? Why is a BOA debit card better than any other debit card?
When a good magician pulls off a trick, he uses enough misdirections to ensure that the audience cannot reconstruct the mechanism by logic deduction. A good magician knows that people are not stupid. If only the brains of BOA knew that too.

